Oxandroplex (oxandrolone) was introduced in 1964 when Searle released the original Oxandroplex. It quickly became a popular drug among athletes among people who were looking for a safer alternative to the main steroid of the time, Methanoplex (methandienone). It remained one of the best-selling drugs for over 2 decades until it was indefinitely discontinued in 1989. Much to the dismay of bodybuilding and powerlifting enthusiasts.
Oxandroplex (oxandrolone) is not very toxic, not very androgenic, moderately anabolic and fairly mild in its effects on the hypothalamic-testicular-pituitary axis of the body. These are its 4 main points, and I’d like to explore each of them a little further; as usual, gym rumours and internet speculation have made this steroid the subject of many misconceptions.
An inherently weak steroid with a high price and low availability, Oxandrolone owes its great popularity to its safety. Unlike oxymetholone, Oxandrolone is considered the safest of all steroids. Its effects are more than well documented and have been around for decades. The medical community values Oxandrolone as a safe alternative to more harmful steroids, which is why it is considered safe for use in children and even in patients suffering from hepatotoxicity as a result of alternating steroids.
Oxandrolone also has little effect on the body’s own natural production of hormones. There was very little negative feedback, meaning that no suppression of gonadotropin-releasing hormone (GnRH, the start of natural testosterone production) was noted with short-term use. This meant that any gains made, however small, were very easily maintained after a cycle. Thus, products such as clomiplex (clomiphene citrate) or tamoxiplex (tamoxifen citrate) combined with oxandrolone consumption were also useless. Easy to maintain low gain indicates low binding to the androgen receptor. While not very high, it should be noted that it has pretty decent binding to the androgen receptor. But the reason for its mild effects is likely due to the low dose used. Rarely, if ever, do doses exceed 20 mg used daily. Either because of convenience or high price. But compared to the doses of other steroids, this is surprisingly low. So it makes sense that the benefits and side effects aren’t particularly noticeable.
For bodybuilders, the best results are seen when Oxandrolone is combined with a high androgenic compound. Either during a mass-stack with flavoured products to increase strength a little more, or in combination with a non-estrogenic compound. This is most beneficial as it can maintain muscle mass, reduce appetite, improve muscle sharpness and maintain strength levels without increasing androgenic risk (acne, prostate hypertrophy, hair loss) when combined with pure androgens (stanozolol, drostanolone). For those looking for safe muscle mass maintenance, stacking Oxandroplex with Primoplex 100 (Methenolone Enanthate) is not a bad investment (but a big investment). Typical Oxandrolone use is estimated at 0.125 mg per pound of bodyweight. For men it should be closer to 0.2 mg per pound, for women 0.08 mg per pound per day.
HOW IT WORKS:
Anabolic steroids work by stimulating the anabolic effects described earlier by binding or connecting to protein receptors inside or on cells that help create new proteins in the cells. This increased biological activity is called an increase in ribonucleic acid activity (RNA activity). Building new proteins helps increase muscle size and strength. Remember, this usually happens in the body. Steroids stimulate or enhance this biological process by binding to protein cell receptors.
Once the drug enters the body, the body begins to process the drug, which involves four processes:
The side effects of steroids are directly related to the dosage.
There are many bodybuilders who take more steroids than they need to see the desired results.